Table 1.
Type, class, protein size and localization of histone deacetylases (HDACs).
| HDAC Type | HDAC Class | Amino Acids | Cellular Localization | Cancer Type | Referencers |
|---|---|---|---|---|---|
| HDAC1 | I | 482 | Nucleus | Lung, gastric, liver, breast, ovarian, prostate, renal, bladder, hematological tumors | [52,53,54,55,56,57,58,59] |
| HDAC2 | I | 488 | Nucleus | Medulloblastoma, gastric, pancreatic, colorectal, breast, ovarian, prostate, renal, bladder, hematological tumors | [54,55,56,57,58,60,61,62,63] |
| HDAC3 | I | 428 | Nucleus and cytoplasm | Lung, gastric, breast, ovarian, prostate, bladder, melanoma, Hematological tumors | [54,55,57,58,62,64,65] |
| HDAC4 | IIa | 1084 | Nucleus and cytoplasm | Hematological tumors | [58] |
| HDAC5 | IIa | 1122 | Nucleus and cytoplasm | Hematological tumors | [58] |
| HDAC6 | IIb | 1215 | cytoplasm | Hematological tumors | [58] |
| HDAC7 | IIa | 912 | Nucleus and cytoplasm | Hematological tumors | [58] |
| HDAC8 | I | 377 | Nucleus, Mitochondria and cytoplasm | Neuroblastoma, melanoma, hematological tumors | [58,65,66] |
| HDAC9 | IIa | 1011 | Nucleus and cytoplasm | Hematological tumors | [58] |
| HDAC10 | IIb | 669 | Cytoplasm | Cervical, chronic lymphocytic leukemia | [59,67] |
| HDAC11 | IV | 347 | Nucleus | Lung | [68] |