Table 2.
The most significant single nucleotide polymorphisms (SNPs) associated with malignant mesothelioma, as identified through genome-wide association studies (GWAS)*.
| SNP | Locus | Gene/Neighboring Genes | Gene Function | References |
|---|---|---|---|---|
| rs17228032 | 11q24.1 | CRTAM, JHY, UBASH3B | Adaptive immune response | [87] |
| rs1379270 | 5q13 | RASGRF2, CKMT2, MSH3 | Apoptosis, Rho and Ras protein and small GTPase mediated signal transduction regulation | [87] |
| rs12540101 | 7p22.2 | SDK1, CYP3A54P, CARD11 | Cell adhesion | [87] |
| rs12701229 | 7p22.2 | SDK1, CYP3A54P, CARD11 | Cell adhesion | [87] |
| rs10089418 | 8p21.3 | LOC286114, LINC02153, LZTS1 | - | [87] |
| rs11126523 | 2p12 | C2orf3, LRRTM4 | - | [87] |
| rs13287752 | 9p21.1 | MIR873, C9orf72 | - | [87] |
| rs282718 | 4q12 | IGFBP7, LINC02390, IGFBP7 | - | [87] |
| rs4707427 | 6q15 | SPACA1, AKIRIN2 | - | [87] |
| rs4895337 | 5q23.1 | FTMT, SRFBP1 | - | [87] |
| rs7958488 | 12p13.31 | CD27 | - | [87] |
| rs8142386 | 22q112 | LOC150185 | - | [87] |
| rs9548166 | 13q13.3 | LINC00571, LINC02334 | - | [87] |
| rs7841347 | 8q24.21 | PVT1, MYC, TMEM75 | Oncogene, Transcription regulation | [88] |
| rs3801094 | 7p21.2 | ETV1, ARL4A, DGKB | Oncogene, Transcription regulation | [88] |
| rs9833191 | 3p24.2 | THRB, NR1D2, MIR4792 | Tumor suppressor, Transcription regulation | [88] |
| rs7632718 | 3q26.2 | SLC7A14, CLDN11, RPL22L1 | Amino acid transport | [88] |
| rs4701085 | 5q35.3 | ADAMTS2, ZNF354C, AX747985 | Collagen degradation | [88] |
| rs2501618 | 1q25.2 | CEP350, TOR1AIP1 | Microtubule anchoring | [88] |
| rs10519201 | 15q21.1 | SHC4, EID1, SEDISBP2L | Apoptosis, Regulation of cell proliferation | [88] |
| rs1508805 | 5q23.1 | PRR16, FTMT | - | [88] |
| rs4290865 | 4q22.1 | FAM190A, GRID2 | - | [88] |
| rs5756444 | 22q12.3 | CXF2RB2, C22orf33, TEX33 | - | [88] |
| rs742109 | 6q21 | PRDM1, ATGS | - | [88] |
| rs9536579 | 13q14.3 | OLFMS, MIR1297 | - | [88] |
* Gene location and function were listed on the basis of gene annotations provided by the National Center for Biotechnology Information’s Online Mendelian Inheritance in Man, available online: https://www.ncbi.nlm.nih.gov/omim (assessed on 8 June 2020), The Human Gene Database, Weizmann Institute of Science, available online: https://www.genecards.org (assessed on 8 June 2020) and the Ensembl genome browser, available online: https://www.ensembl.org/index.html (assessed on 8 June 2020).