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. 2020 Jun 8;12(6):1497. doi: 10.3390/cancers12061497

Figure 2.

Figure 2

Organization of the tumor cells and microenvironment in (a). PCMZL: Infiltrate made of small centrocyte-like B-cells, lymphoplasmacytoid cells, plasma cells and reactive T cells admixed with a FDC network surrounded by marginal zone B cells; (b). PCFCL: Infiltrate made of centrocytes and centroblasts often with a FDC network and scattered reactive T cells; (c). PCDLBCL, LT: A monomorphic population of large atypical cells ressembling centroblasts and immunoblasts. The t (14; 18) translocation is extremely rare in PCFCL, unlike in primary nodal follicular lymphoma. The PCDLBCL, LT is characterized by frequent MYD88 L265P mutations, which helps discriminate PCDLBCL, LT from PCFCL with large cells, in which the MYD88 L265P mutation is absent. Abbreviations: PCMZL, primary cutaneous marginal zone lymphoma; PCFCL, primary cutaneous follicle center lymphoma; PCDLBCL, LT, primary cutaneous diffuse large B-cell lymphoma, leg type; DC, dendritic cell.