Table 2.
Upregulated genes after six months of RYGB that are involved in the onset of obesity and insulin pathway (p-value < 0.05). The fold change results were derived from the microarray assay.
| Symbol | Gene Name | Fold Change * |
|---|---|---|
| Obesity | ||
| EPS8 | Epidermal growth factor receptor pathway substrate 8 | 5.57 × 106 |
| PTPN2 | Protein tyrosine phosphatase, non-receptor type 2 | 2.79 × 106 |
| ACTR3 | ARP3 actin-related protein 3 homolog | 2.32 × 106 |
| RPS6KA3 | Ribosomal protein S6 kinase | 2.45 × 106 |
| MAPK9 | Mitogen-activated protein kinase 9 | 2.26 × 106 |
| RAP1B | RAP1B member of RAS oncogene family | 5.51 × 106 |
| PLA2G4A | Phospholipase A2 | 9.65 × 106 |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 | 6.55 × 106 |
| Insulin Pathway | ||
| EIF4E | Eukaryotic translation initiation factor 4E | 3.76 × 106 |
| IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells kinase beta | 3.90 × 106 |
| PHKB | Phosphorylase kinase beta | 4.13 × 106 |
| MAPK9 | Mitogen-activated protein kinase 9 | 2.26 × 106 |
| PPP1CB | Protein phosphatase 1, catalytic subunit, beta isozyme | 2.19 × 106 |
| SOCS4 | Suppressor of cytokine signaling 4 | 4.13 × 106 |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 alpha | 6.55 × 106 |
* p-value < 0.05.