Figure 6.

TFs involved in the effector functions of NK cells. The 3-D protein structural motifs of TFs involved in the development and functions of NK cells are shown. Most TFs enhance both cytotoxicity and IFN-γ production of NK cells (black font). However, FoxO1 suppresses both effector functions as a balance (red). Current evidence shows that Ets-1 is involved only in cytotoxicity and IRF-2 and Gata3 are only involved in IFN-γ production. Tox2 and PU.1 may contribute to the IFN-γ production, though no direct evidence exists. Notch, Runx3, and Aiolos are not involved in NK cell effector functions. The ‘?’ in Figure 6 represents no direct evidence showing the effect on IFN-γ production.