Table 2.
Univariate and multivariate Cox proportional hazards models of prognostic factors for NPC survival.
| Variables | Cohort n = 565 |
Hazard Ratio (95%CI) | |||
|---|---|---|---|---|---|
| Univariate | p-Value | Multivariate | p-Value | ||
| Sex | |||||
| Female | 93 (16.5%) | 1 | 0.372 | 1 | 0.773 |
| Male | 472 (83.5%) | 1.26 (0.76–2.11) | 1.08 (0.640–1.82) | ||
| Age | |||||
| ≤60 years | 420 (74.3%) | 1 | <0.001 *** | 1 | <0.001 *** |
| >60 years | 145 (25.7%) | 2.05 (1.43–2.95) | 2.11 (1.45–3.09) | ||
| Stages of Cancer (AJCC) a | |||||
| I and II | 231 (40.9) | 1 | <0.001 *** | 1 | <0.001 *** |
| III and IV b | 334 (59.1) | 3.88 (2.45–6.15) | 4.02 (2.43–6.67) | ||
| Treatments | |||||
| CCRT | 470 (83.2%) | 1 | 1 | ||
| RT | 80 (14.2%) | 0.78 (0.44–1.39) | 0.405c | 1.29 (0.67–2.48) | 0.454e |
| CT | 9 (1.5%) | 29.63 (12.14–72.34) | <0.001 ***d | 25.34 (9.83–65.32) | <0.001 ***f |
| Aspirin Use | |||||
| No | 452 (80.0%) | 1 | <0.001 *** | 1 | <0.001 *** |
| ≥180 days | 113 (20.0%) | 0.28 (0.14–0.55) | 0.23 (0.12–0.46) | ||
Abbreviations: 95% CI 95% confidence interval; CCRT concurrent chemoradiotherapy; RT radiotherapy; CT chemotherapy; a AJCC Cancer Staging 7th Edition; b Stages IVa and IVb only; c, e Comparing RT to CCRT; d, f Comparing CT to CCRT; *** p ≤ 0.001.