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. 2020 Jun 23;21(12):4469. doi: 10.3390/ijms21124469
CML Chronic Myeloid Leukemia
PK Protein Kinase
TK Tyrosine Kinase
TKI Tyrosine Kinase Inhibitor
RTK Receptor Tyrosine Kinase
NRTK Non-Receptor Tyrosine Kinase
VEGFR Vascular Endothelial Growth Factor
PDGF Platelet Derived Growth Factor
Src Sarcoma
JAK Janus Kinase
ABL Abelson (gene)
BCR Breakpoint Cluster Region (gene)
PI3K Phosphoinositide 3-Kinase
STAT Signal Transducer and Activator of Transcription (protein)
CP Chronic Phase
AP Accelerated Phase
BC Blast Crisis
Asp Aspartate
Phe Phenylalanine
Gly Glycine
ATP Adenosine Triphosphate
DFG Aspartate-Phenilalanine-Glycine
Thr Threonine
HSCT Hematopoietic Stem Cells Transplantation
HCT Hematopoietic Cell Transplantation
INF Interferon
CHR Complete Hematological Response
MMR Major Molecular Response
CCR Complete Cytogenetic Remission
Ph Philadelphia (chromosome)
Ph+ Philadelphia positive
P-gp Glycoprotein P
OCT Organic Cation Transporter
PDGFR Platelet Derived Growth Factor Receptor
UK United Kingdom
NAACCR North American Association of Central Cancer Registries
ELN European Leukemia Net
NCCN National Comprehensive Cancer Network
CI Confidence Interval
STIM Stop Imatinib
LSC Leukemic Stem Cells
ALL Acute Lymphoblastic Leukemia
CMR Complete Molecular Response
FDA Food and Drug Administration
EMA European Medicinal Agency
R/I Resistance/Intolerance
SAE Severe Adverse Event
HLA Human Leukocyte Antigen
CIBMTR Center for International Blood and Marrow Transplant Research
OS Overall Survival
LFS Leukemia-Free Survival
MSD Matching Sibling Donor
HCT Hematopoietic Cell Transplantation
HRQOL Health-Related Quality of Life
ISD Identical Sibling Donor
TFR Treatment-free Remission
QoL Quality of Life
DMR Deep Molecular Response
EURO-SKI European Stop Tyrosine Kinase Inhibitor
ESMO European Society for Medical Oncology
RQ-PCR Real-time Quantitative Polymerase Chain Reaction