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. 2020 May 31;12(6):1421. doi: 10.3390/cancers12061421

Figure 2.

Figure 2

Oncogenic H-Ras plays a major role in tumor transformation via two major pathways, PI3K/AKT and MEK/ERK [73,74]. H-Ras recruits intracellular Gal-1 from the cytosol. This interaction enhances H-Ras-mediated cell transformation. Since Gal-1 has no effect on the membrane localization of inactive H-Ras, Ras activation, via GTP binding is needed for the H-Ras/Gal-1 interaction. Gal-1 is then able to enhance H-Ras-GTP, leading to an increase in Raf-1 recruitment, which culminates in a sustained activation of the MEK-ERK pathway and enhanced cell transformation [63].