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Galectin-3 as an inhibitor of the apoptotic response. Gal-3 can translocate from the cytosol and/or the nucleus to the mitochondria, inhibiting stressors of the mitochondrial membrane potential and subsequent release of Cyt C. In response to apoptotic stimuli, Gal-3 can translocate to the mitochondria and interact with Bax and prevent its function, as well as other pro-apoptotic Bcl-2 family members, subsequently preventing the formation of pro-death promoting homodimers.
