Table 3.

Comparison of different tests of cure at 6 months and margin status at LLEZT to predict recurrence of HSIL lesions at 24-month follow-up. Recurrence of HSIL overall at 24 months was 2.4%.

Test of Cure	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
Colposcopy	0.00 (0.00–0.30)	0.97 (0.95–0.98)	0.00 (0.00–0.24)	0.98 (0.96–0.99)
Cytology	0.40 (0.17–0.69)	0.99 (0.98–1.00)	0.67 (0.30–0.94)	0.99 (0.97–0.99)
HrHPV	1.00 (0.70–1.00)	0.85 (0.81–0.88)	0.12 (0.07–0.22)	1.00 (0.99–1.00)
Margins	0.60 (0.31–0.83)	0.82 (0.78–0.85)	0.08 (0.03–0.15)	0.99 (0.97–1.00)

PPV = positive predictive value, NPV = negative predictive value CI confidence interval, HrHPV high-risk human papillomavirus.