Table 4.

Recurrence of HSIL lesions during the 24-month follow-up after LLETZ: according to the resection margin status of the first LLETZ and separately for all women regardless for histopathology and according to whether reoperation for affected margins was performed.

Margins Affected	Margin Status	6 Months n/N (%) *	12 Months n/N (%)	18 Months n/N (%)	24 Months n/N (%)	All Cumulative n/N (%)
Any Margin
No re-LLETZ, only HSIL (n = 419)	Free (n = 339)	2/339 (0.6)	2/51 (3.9)	0/28 (0.0)	0/236 (0.0)	4/339 (1.2)
	Affected (n = 80)	3/80 (3.8)	3/19 (15.8)	0/15 (0.0)	0/47 (0.0)	6/80 (7.5)
All LLETZ (n = 491)	Free (n = 368)	2/368 (0.5)	2/56 (3.6)	0/36 (0.0)	0/249 (0.0)	4/368 (1.1)
	Affected (n = 123)	3/123 (2.4)	3/26 (11.5)	0/23 (0.0)	0/74 (0.0)	6/123 (4.9)
No re-LLETZ	Affected (n = 85)	2/85 (2.4)	3/20 (15)	0/16 (0.0)	0/469(0.0)	5/85 (5.8)
Re-LLETZ	Affected (n = 38)	1/38 (2.6)	0/6 (0.0)	0/7 (0.0)	0/25 (0.0)	1/38 (2.6)
Ectocervical margins (66/123)
All LLETZ	Affected	2/66 (3.0)	3/12 (25)	0/15 (0.0)	0/40 (0.0)	5/66 (7.6)
No re-LLETZ	Affected	2/53 (1.9)	3/10 (30)	0/11 (0.0)	0/29 (0.0)	4/52 (7.7)
Re-LLETZ	Affected	0/13 (0.0)	0/2 (0.0)	0/4 (0.0)	0/11 (0.0)	1/14 (7.1.)
Endocervical margins (37/123)
All LLETZ	Affected	0/37 (0.0)	0/9 (0.0)	0/5 (0.0)	0/24 (0.0)	0/37 (0.0)
No re-LLETZ	Affected	0/20 (0.0)	0/7 (0.0)	0/3 (0.0)	0/14(0.0)	0/20 (0.0)
Re-LLETZ	Affected	0/17 (0.0)	0/3 (0.0)	0/2 (0.0)	0/10 (0.0)	0/17 (0.0)
Both Margins (20/123)
All LLETZ	Affected	1/20 (5)	0/3 (0.0)	0/3 (0.0)	0/10 (0.0)	1/20(5.0)
No re-LLETZ	Affected	1/12 (9.1)	0/2 (0.0)	0/2 (0.0)	0/6 (0.0)	1/11 (9.1)
Re-LLETZ	Affected	0/8 (0.0)	0/1 (0.0)	0/1 (0.0)	0/4 (0.0)	0/9 (0.0)

* n = cases of histological HSIL (high-grade cervical intraepithelial lesion), N = cases assessed, LLETZ large loop excision of the transformation zone.