Figure 3.

Example of a patient treated with a personalised dosimetry approach, with a lesion accurately treated (tumor dose higher than the 205 Gy threshold). (A) Based CT image of 15 cm unifocal right HCC with the invasion of the veina cava in a 64-year-old patient with good performance status (ECOG 0) and liver functions (Child Pugh A5). The patient received a treatment of the right lobe with 7.06 GBq of ⁹⁰Y glass microspheres using the personalized dosimetry approach delivering 294 Gy to the large lesion and 173 Gy to the right lobe. CT image, 3 months after SIRT, partial response of the huge lesion was obtained using EASL criteria, as no recurrence on the left lobe and no extra hepatic spread (B). The patient was still in good performance status (ECOG 0) and liver functions (Child Pugh A5) and a right hepatectomy was performed with veina cave reconstruction. At last follow-up evaluation, 22 months after SIRT, the patient was still in complete response.