Figure 4.

The subcellular localization of the interplay network of the human oncogenic drivers as described in the text. The most decisive and universal drivers—mutant p53, KRAS, and hyperactive CMYC—are highlighted in red; the rest of the universal drivers are in orange and additional oncogenic partner factors described in the text are shown in purple. The links between oncoproteins of different pathways are shown either by red arrows or, when a direct protein complex is formed, by overlapping symbols.