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. 2020 Jun 25;21(12):4532. doi: 10.3390/ijms21124532

Figure 1.

Figure 1

The inhibitory effects of low-dose ionizing radiation (LDIR) therapy on amyloid-β (Aβ) accumulation and cognitive dysfunction in 5XFAD mice. (A) Schematic diagram of the experimental procedure. (B) Histochemical staining for thioflavin S was performed to identify amyloid plaques in the cerebral cortex and hippocampal dentate gyrus (DG) of the sham- and LDIR-treated 5XFAD mice (scale bar = 250 μm). (C) Aβ-positive areas in the cerebral cortex and dentate gyrus of the sham- and LDIR-treated 5XFAD mice were quantified and plotted as a percentage. (D) Representative of swimming paths was recorded on videotape during the test session of the Morris water maze. (E) Latency to escape time of the mice was measured. Repeated-measures two-way ANOVA with Fisher’s post hoc test compared to 5XFAD+Sham mice. (F) Measurement of quadrant time to spend in the hidden platform. Data are presented as mean ± SD (n = 10 mice in sham-treated 5XFAD mice and n = 14 mice in LDIR-treated 5XFAD mice). # p < 0.05 and ### p < 0.001 indicate significant differences between the sham- and LDIR-exposed 5XFAD mice.