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. 2020 May 30;12(6):1414. doi: 10.3390/cancers12061414

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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O-link screening for cytokines as potential biomarkers. (A) Baseline and follow-up blood samples from four patients were analyzed by O-link for the levels of 92 immuno-oncology proteins. All four patients were treated with first-line pembrolizumab. Normalized Protein eXpression (NPX) expression values (arbitrary units) are visualized on the heatmap. White color indicate undetectable cytokine level. The following cytokines were excluded as their concentrations were below detection limit: Fibroblast growth factor 2 (FGF2), Interleukin (IL) 1α, IL2, IL5, IL21, IL33, IL35, and tumor necrosis factor α (TNFα). (B) Graphs display plasma level changes for Interferon γ-induced protein 10 (IP10), monocyte chemoattractant protein 1 (MCP1), IL6, and IL8 over timer. A.U. = arbitrary units. T.I. = treatment initiation.