Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 19;12(6):1631. doi: 10.3390/cancers12061631

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Structure-based design of Gα_i2 Inhibitors. (A) Representative examples of Gα_i1 Inhibitors. (Bi) Docked output of compound 9827 (12) at the active site of Gα_i1–GDP, showing the placement of the thiophene-hydroxyl and benzothiophene sulfur groups. (Bii) Overlay of docked orientations of 12 in the presence (cyan) or absence (yellow) of Mg²⁺ ion. (C) Overlay of docked orientations of 12 (cyan) and 9a (teal) (Ci), and 12 (cyan) and 9b (grey) (Cii). (Di) Overlay of the docked outputs of 12 (cyan) and 13 (orange). (Dii) Overlay of the docked outputs of 12 (cyan), 13 (orange) and 14 (brown).