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. 2020 Jun 19;12(6):1631. doi: 10.3390/cancers12061631

Figure 5.

Figure 5

Inhibition of Gαi2 decreased migratory capability of renal, breast and ovarian cancer cells. (A) E006AA cells were subjected to transwell migration assay, incubated with or without the three inhibitors (9b, 13 and 14) at the final concentration of 10 μM, in the presence (+) or absence (−) of EGF (10 ng/mL). The results are expressed as migration index. Each bar represents mean ± SEM. (B) SKOV3 cells were transfected with control and Gαi2 siRNAs and then subjected to transwell migration assays in the presence (+) or absence (−) of EGF (10 ng/mL). Results are expressed as migration index. Each bar represents mean ± SEM. (C) SKOV3 cells were incubated with or without compound 14 at 10 μM, and then subjected to transwell migration assay in the presence (+) or absence (−) of EGF (10 ng/mL). The results are expressed as migration index. Each bar represents mean ± SEM (* p ≤ 0.05; ** p ≤ 0.01).