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. 2020 Jun 24;12(6):1685. doi: 10.3390/cancers12061685

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TMB and clinically relevant genetic alterations. For targetable driver alterations (green and blue), TKI-sensitive mutations were counted. Regarding KEAP1, ARID1A, STK11, and POLE, all non-synonymous aberrations (red) were considered. Data are presented as box plots with a 95% confident interval. The line indicates the mean, the + indicates the median. Statistical analysis by ANOVA revealed significant differences in TMB between EGFR and KEAP1, ARID1A, POLE, and STK11 (#) mutated groups; between ALK fusion and KEAP1, ARID1A, POLE, and STK11 mutated groups (§); and between targetable driver mutations and all red groups (¶); and lastly, between targetable and non-targetable driver mutation groups (¶¶).