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. 2020 May 29;12(6):1601. doi: 10.3390/nu12061601

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Concentration-dependent inhibition of URAT1-mediated urate transport by unsaturated fatty acids. The effects of each unsaturated fatty acid (0, 0.1, 0.3, 1, 3, 10, 30, 100, or 300 μM) on URAT1-mediated urate transport were investigated with the urate uptake assay. (a) α-Linolenic acid (ALA); (b) γ-linolenic acid; (c) eicosadienoic acid; (d) eicosatrienoic acid; (e) ω-3 eicosatetraenoic acid; (f) arachidonic acid (ω-6 eicosatetraenoic acid); (g) eicosapentaenoic acid (EPA); (h) henicosapentaenoic acid; (i) docosahexaenoic acid (DHA). Data are expressed as the mean ± SD; n = 4.