Table 1.

Comparison of the proposed method with other reported methods to determine Gefitinib (GEF) in different sample matrices.

Matrix	Extraction Method	Detection System	Extraction Time (min)	LOD (ng/mL)	Linear Range (ng/mL)	%RSD	Ref.
Water	SPE	HPLC-UV	20	4.6	15–300	1.0	This work
Human Plasma	SPE	HPLC-UV	20	25.0	80–600	1.1	This work
Polymeric nano-formulation	-	HPLC-UV	-	37.8	200–1200	<1	[6]
Tablet	-	HPLC-UV	-	90	5000–25,000	0.877	[16]
Human Plasma	LLE	HPLC-MS	15	-	5–3000	<5	[17]
Human Plasma	Protein precipitation	HPLC-MS	10	-	1–1000	<15	[18]
Rat Plasma	Protein precipitation	HPLC-MS	10	-	5–1000	<15	[18]
Human Plasma	LLE	LC-MS/MS	>30	-	0.5–1000	<15	[19]

LOD: limit of detection; RSD: relative standard deviation; SPE: solid-phase extraction; LLE: liquid–liquid extraction.