Figure 3.

The cluster found in the protein–protein interaction network map of the 194 genes encoded differentially proteins identified in the AuNP–protein corona after the interaction of AuNPs (10.02 ± 0.91 nm) (30 min, incubation) with serum samples belonging to 42 breast cancer patients. Based on the STRING database, 29 differential expressed proteins formed a network core with proteins of the immune system, of which some of them are neutrophil-derived granule proteins. The meaning of the different edge colors is related to the reactome pathways. Red: immune system; blue: innate immune system; yellow: cytokine signaling in the immune system, green: neutrophil degranulation.