TABLE 1:
Summary of results from the high-throughput screen for a subset of 21 randomly selected genes to be screen using confocal microscopy.
| High-throughput screen results | ||||
|---|---|---|---|---|
| Gene name | Number of nuclei | Mean EFC ratio | Standard error | Statistically significant? |
| CXXC1 | 805 | 4.85 | 0.07 | Yes |
| HIST1H3G | 1823 | 4.97 | 0.04 | Yes |
| HIST1H1T | 533 | 5.00 | 0.07 | Yes |
| SUZ12 | 807 | 5.03 | 0.06 | Yes |
| WSB2 | 1524 | 5.08 | 0.05 | Yes |
| MTA2 | 909 | 5.11 | 0.07 | Yes |
| ZRANB3 | 692 | 5.25 | 0.08 | Yes |
| INO80B | 1795 | 5.29 | 0.05 | Yes |
| FOXP1 | 505 | 5.34 | 0.10 | Yes |
| DIDO1 | 687 | 5.35 | 0.09 | Yes |
| ARID4A | 1015 | 5.37 | 0.06 | Yes |
| MAP3K7 | 2048 | 5.42 | 0.05 | Yes |
| TAF7 | 850 | 5.43 | 0.08 | Yes |
| RAD54L2 | 1946 | 5.48 | 0.04 | Yes |
| TP53 | 139 | 6.17 | 0.23 | Yes |
| RAD51 | 305 | 6.20 | 0.14 | No |
| LEO1 | 1283 | 6.30 | 0.07 | No |
| GADD45A | 902 | 6.83 | 0.08 | No |
| SCRAM | 15677 | 6.90 | 0.04 | N/A |
| FBL | 1036 | 6.92 | 0.08 | No |
| SMARCB1 | 819 | 7.04 | 0.09 | No |
Statistical significance of gene depletion EFC ratios, relative to the scrambled siRNA control, was determined by the two-tailed Bonferroni-corrected nonparametric Dunn’s test for p < 0.05.