FIGURE 5:

Computational model of the ommatidium predicts cell-type-specific mechanical response. (A) Schematic of the tension-elasticity model of the ommatidial cluster showing the edge tensions, bulk elasticity parameters in the cone cell cluster (blue), primary pigment cell (green), and the interommatidial cell clusters (red). (B) Simulations of ablation experiments by reducing bulk tension in one of the primary pigment cells (marked by a star). Left to right: evolution of colony morphology on ablation. (C) Model prediction for the dynamics of the apical area (normalized) for the different cell clusters in the ommatidia, on ablation at t = 0. (D) Model prediction for the dynamics of the cell shape index (perimeter/√area, normalized) for the different cell clusters in the ommatidia, on ablation at t = 0. (E) Simulation of ablation experiments for a softer cone cell (CC) cluster. (F, G) Dynamics of cell area (F) and cell shape index (G) in the ablation simulation showing significant deformation of the cone cell cluster, inconsistent with experimental data. (H) Simulation of the hypercontraction in the right primary pigment cell (marked by red arrows). (I) Model prediction for the dynamics of the apical area (normalized) for the different cell clusters in the ommatidia, on the induction of hypercontraction in the right primary pigment cell at t = 0. (J) Model prediction for the dynamics of the cell shape index (perimeter/√area, normalized) for the different cell clusters in the ommatidia on the induction of hypercontraction in the right primary pigment cell at t = 0.