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. 2020 Jun 1;31(12):1232–1245. doi: 10.1091/mbc.E20-02-0125

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FIGURE 7: — Proposed organization of eIF2B decamers in the filament. The repeating units in the eIF2B filament have a size and overall shape similar to the cryo-EM structure of the eIF2B decamer (Adomavicius et al., 2019; Gordiyenko et al., 2019). The proposed stacking of three cryo-EM structures of eIF2B is compatible with the subtomogram average of the filament, which contains three eIF2B units. This suggests that the filaments are generated by polymerization of eIF2B decamers. Light green = Gcn3 (α) subunit; purple = Gcd7 (β) subunit; light blue = Gcd1 (γ) subunit; green = Gcd2 (δ) subunit; blue = Gcd6 (ε) subunit of eIF2B; and yellow = Sui2 (α) subunit of eIF2.