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. 2020 Jun 11;12(6):1754. doi: 10.3390/nu12061754

Figure 2.

Figure 2

Average meal patterns over the 14 days of daily oral RK and diet access. Meal patterns are from the nocturnal period. Data are represented as means ± standard error of the mean (SEM). High-fat diet (45% fat; HFD, solid lines) and low-fat diet (10% fat; LFD, stripped line) and oral gavage with raspberry ketone (RK) or vehicle (50% propylene glycol, 40% water, and 10% dimethyl sulfoxide; DMSO) for 14 days. Comparisons are separate within each sex. Meal patterns were averaged over fourteen days of dosing and diet exposure. (A): Meal frequency; average number of meals each day, (B): meal size (kcal), (C): meal duration (min), (D): meal eating rate (kcal/min), and (E): satiety ratio (inter meal interval in min/kcal). * indicates overall diet difference from LFD (p < 0.05), ** indicates overall diet difference from LFD (p < 0.005), # indicates overall dose difference from vehicle (p < 0.05), ## indicates overall dose difference from vehicle (p < 0.01), && indicates overall dose difference from RK200 dose (p < 0.001), & indicates overall dose difference from RK200 dose (p < 0.05). HFD-Vehicle (males: n = 14, females n = 4, HFD-RK (200 mg/kg) (males: n = 8, females: n = 6), HFD-RK (400 mg/kg) (males: n = 7, females: n = 6), LFD-Vehicle (males: n = 16, females: n = 8) LFD-RK (200 mg/kg)(males: n = 7, females: n = 8), and LFD-RK (400 mg/kg)(males: n = 8, females: n = 8).