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. 2020 Jun 11;12(6):1754. doi: 10.3390/nu12061754

Figure 6.

Figure 6

Hemodynamic measurements during the last two days of the 14-day daily oral RK and diet access. Blood pressure and heart rate were measured by noninvasive tail-cuff method. Data are represented as means ± standard error of the mean (SEM). High-fat diet (45% fat; HFD, solid lines) and low-fat diet (10% fat; LFD, stripped line) and oral dosed with raspberry ketone (RK) or vehicle (50% propylene glycol, 40% water, and 10% dimethyl sulfoxide; DMSO) for 14 days. Comparisons are separate within each sex. Hemodynamic measurements were averages over the last 2 days of dosing and diet exposure. (A): Systolic blood pressure (mm Hg), (B): diastolic blood pressure (mm Hg), (C): mean blood pressure (mm Hg), (D): heart rate (beats per minute; BPM). # indicates overall dose difference from vehicle and RK 200 mg/kg (p < 0.05), ## indicates overall dose difference from vehicle and RK 200 mg/kg (p < 0.005) & indicates overall dose difference from RK200 dose (p < 0.05). HFD-Vehicle (males: n = 12, females n = 12), HFD-RK (200 mg/kg) (males: n = 12, females: n = 11), HFD-RK (400 mg/kg) (males: n = 11, females: n = 11), LFD-Vehicle (males: n = 11, females: n = 11) LFD-RK (200 mg/kg)(males: n = 11, females: n = 11), and LFD-RK (400 mg/kg) (males: n = 11, females: n = 12).