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. 2020 Jun 22;12(6):1860. doi: 10.3390/nu12061860

Table 1.

List of the included cohort study.

Study Name Country Original Cohort (Established-Last Outcome Assessment) n Assessment Caffeine Consumption Amount of Caffeine Consumption The Diagnosis of PD
Ascherio et al. [17] USA Health Professionals’ Follow-Up Study and Nurses’ Health Study (1976 and 1986/1994) 135,916 Semiquantitative food-frequency questionnaire (SFFQ) Caffeine was 137 mg per cup of coffee, 47 mg per cup of tea, 46 mg per can
or bottle of cola beverage, and 7 mg per serving of chocolate candy.
Self-report and medical records
Ascherio et al. [22] USA Nurses’ Health
Study (1976/1998)
121,700 women Semiquantitative food-frequency questionnaire (SFFQ) Caffeine was 137 mg per cup of coffee, 47 mg per cup of tea, 46 mg per can
or bottle of cola beverage, and 7 mg per serving of chocolate candy.
Medical records
Grandinetti et al. [21] USA Honolulu Heart Program-Japanese and Okinawan ancestry (1965/1991) 8006 men Questionnaires NA Medical records
Hu et al. [23] FIN Four independent cross-sectional population surveys
were carried out in five geographic areas of Finland in
1982, 1987, 1992, and 1997 (1982/2002)
29,335 Self-administered questionnaire Cups of coffee National Social Insurance Institution’s Register
Liu et al. [18] USA NIH-AARP Diet and Health Study (1995/2010) 566,401 Diet History
Questionnaire
Nutrient calculation:
1994–1996
US Department of Agriculture’s Continuing Survey of Food
Intakes by Individuals.
Interview and copy of medical records
Palacios et al. [25] USA CPS II–Nutrition cohort (1992/2007) 184,190 Food Frequency Questionnaire 137 and 47 mg per cup of coffee and tea,
respectively, 46 mg per can or bottle of cola; and 7 mg per serving of chocolate.
Interview and copy of medical records
Sääksjärvi et al. [15] FIN Finnish Mobile
Clinic Health
Examination Survey (1973/1994)
7246 Self-administered,
health questionnaire
Cups of coffee National Social Insurance Institution’s Register
Tan et al. [24] SG Singapore Chinese Health Study (1993/2005) 63,257 A validated, semiquantitative food frequency section questionnaire Singapore Food Composition Table, a food-nutrient database that lists the levels of 96 Nutritive/nonnutritive components (including caffeine) per 100 g of cooked food and beverages Interview and linkage database to medical record
Wirdefeldt et al. [16] SE Swedish Twin Registry (1961 and 1973/without clear mentioning) 52,149 Questionnaires Did not provide the formula Inpatient Discharge Register and Cause of Death Register