Table 2.

Relative Impact in Hepatitis C Virus Treatment Initiation Rates

	Relative impact of removing significant liver fibrosis restrictions (IRR)	Adjusteda relative impact of removing significant liver fibrosis restrictions (IRR)
All CCC participants	1.8 (1.4, 2.4)	1.8 (1.3, 2.5)
PWIDb	3.8 (2.0, 7.3)	3.6 (1.8, 7.4)

Results following removal of significant liver fibrosis restrictions overall (n = 1130) and specifically among PWID (n = 460). Each cell represents a separate regression analysis, for each we included fixed effects for province and year. The natural logarithm of each participant’s time at risk (in years) was used as an offset. Standard errors are clustered by individuals. Full regression tables for each analysis are available in Supplementary Table 2. Abbreviations: CCC, Canadian Coinfection Cohort Study; HCV, hepatitis C virus; HIV, human immunodeficiency virus; IRR, incident rate ratio; PWID, people who inject drugs.

^aAdjusted models included fixed covariates included age (centered at mean), sex, men who have sex with men, and HCV genotype. The time-varying covariates included income (<$18 000 CAD) [13], injection drug use (within the 6 months), undetectable HIV RNA (<50 copies/mL), and significant fibrosis.

^bPWID were defined as those self-reporting injection drug use within the 6 months of cohort visits. This was treated as a time-varying variable.