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. 2020 Jul 10;22:168. doi: 10.1186/s13075-020-02259-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Chondroclasts and osteoclasts are transcriptionally distinct. Microarray analysis of RNA isolated from laser-captured chondroclasts and osteoclasts. Gene expression profiling for differentially expressed genes was compared in a multivariate analysis via ClustVis using hierarchical clustering and principal component analysis. The expression analysis led to the successful segregation of these cell populations by chondroclasts vs osteoclasts via principal component analysis (a, b) and hierarchical clustering analysis (c). b The PCA plot shows PC1 and PC2 indicating 58.1% and 15% of the total variance, respectively