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. 2020 Jul 10;22:168. doi: 10.1186/s13075-020-02259-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Network analysis reveals the abundance of structured networks of metabolic pathways, ATP synthesis, and proteasome pathways in chondroclasts. PPI network of genes upregulated in chondroclasts was constructed using STRING database utilizing experimentally validated interactions with a combined PPI score of > 0.7. Subnetwork analysis in the PPI network using MCODE identified the significant modules/clusters. a The cluster analysis in PPI network resulted in 10 clusters. Top 7 clusters were shown which include 67 nodes and 396 edges. Cluster 1 (b), cluster 2 (c), and cluster 3 (d) of top three network clusters in the subnetwork analysis of PPI network of IDD-related genes and enriched GO terms for biological processes were shown. The cluster networks were visualized by Cytoscape (version 3.7.1). All nodes are significantly enriched at FDR P value < 0.05