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. 2020 Jun 25;12(6):1894. doi: 10.3390/nu12061894

Figure 2.

Figure 2

Comparison of TE status and composite biomarkers of TE in SSc patients versus controls. Patients suffering from SSc-PAH display reduced serum Se and Zn status as compared to healthy controls (HC). Differences are observed for (A) total Se and, (B) serum SELENOP concentrations, as well as (C) serum GPx3 activity and (D) total serum zinc (Zn) concentrations. In comparison, (E) total serum Cu concentrations do not differ between the groups. Concentration of the Cu transporter CP is elevated in SSc-PAH patients as compared to HC. Similar differences are detected for (F) serum ceruloplasmin (CP) concentrations, (G) serum Cu/Zn ratio, (H) serum Cu/Se ratio, and (I) serum CP/SELENOP ratio. Comparisons were analysed by Kruskal-Wallis statistics and Dunn’s multiple comparisons test. All tests were two-sided and p-values < 0.05 were considered statistically significant; * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.001 and **** indicates p < 0.0001.