Figure 5.

Effect of lipid injury on microRNA target differentially expressed gene pathways expression in hippocampal microvessels. Heat map of differentially expressed gene pathways and miRNA target gene pathways. Comparisons of pathways of differentially expressed genes and pathways of miRNA target genes identified a group of pathways such as the chemokine signaling pathway, focal adhesion, gap junction, insulin signaling, Nf-kB signaling or Gap junctions, and pathways that regulate endothelial cell interaction and permeability in common. The representative integrated analysis of the differentially expressed genes, and target genes of differentially expressed miRNAs for the focal adhesion signaling pathway is detailed. Blue = differentially expressed genes; yellow = target genes of differentially expressed miRNAs; color gradation from blue to yellow = genes identified to be both differentially expressed and to be targets of differentially expressed miRNAs.