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. 2020 May 26;9(6):688. doi: 10.3390/foods9060688

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of taurine on the shift from M1 to M2 macrophages in fat tissues. (A) The relative basal mRNA expression levels of the macrophage marker genes (F4/80) and M1 (CD11c and CD68) and M2 (CD206 and CD163) macrophage-specific marker genes were investigated to determine how many M1 and M2 macrophages existed in iWAT and BAT of the normal diet (N) group. (B) The effect of HFD or taurine supplementation on the mRNA expression levels was investigated to determine if HFD or taurine supplementation affected the infiltration of macrophages into fat tissues and the shift of M1/M2 macrophages in iWAT and BAT: N normal diet group (n = 5), HFD high-fat diet group (n = 5), and H + Tau HFD + taurine (2% in drinking water) group (n = 5). Differences between the three groups were analyzed using the nonparametric Kruskal–Wallis test as described in Figure 2. Differences were considered statistically significant at p < 0.05. * p < 0.05; ns not significant.