Scheme 1.
Illustration of the proposed mechanism of nanoMIL-89 cellular uptake and internalization into endocytic vesicles. (i) NanoMIL-89 were uptaken by the cells by endocytosis, packaged into an endosome, and (ii) fused with a lysosome, forming (iii) an endolysosome vesicle. The reassembly and aggregation of nanoMIL-89 is triggered by the acidic environment within the interior membrane of the lysosome.