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. 2020 Jul 11;13:101. doi: 10.1186/s12920-020-00753-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Correlation between corresponding LBC and FFPE specimens in VAF, Mutation counts, TMB, and MSI. a The VAF of mutated genes obtained from 7 endometrial LBC and that of the same gene mutations from corresponding FFPE were plotted, showing a good correlation between the selected LBC and FFPE specimens. The data consisted of VAF of 42 genes detected by NGS analysis in 7 cases with paired LBC and biopsy specimens. b Concordance of mutation counts, TMB, and MSI scores in paired LBC and FFPE (biopsy and resection) specimens from the 7 cases. Bx, biopsy; SR, surgical resection; L, LBC; MMR-D, mismatch repair protein deficiency