Table 1.
Region of interests of custom panel
| 60 genes | 17 MSI regions | |||||
|---|---|---|---|---|---|---|
| Target | Loci | Gene | ||||
| AKT1 | CTNNB1 | MAP2K1 | PIK3CA | Bat-25 | chr4:55598208–55,598,241 | KIT |
| APC | DDR2 | MAP2K2 | PIK3R1 | Bat-26 | chr2:47641403–47,641,591 | MSH2 |
| ATM | EGFR | MAP2K4 | PMS2 | MONO-27 | chr2:39564890–39,564,926 | MAP4K3 |
| AR | ERBB2 | MED12 | PTEN | NR-21 | chr14:23652343–23,652,372 | SLC7A8 |
| ARID1A | ERBB3 | MET | RB1 | NR-24 | chr2:95849358–95,849,389 | ZNF2 |
| BARD1 | ERBB4 | MDM2 | RAD51 | MSI-1 | chr1:201754407–201,754,432 | NAV1 |
| BRAF | ESR1 | MLH1 | STK11 | MSI-3 | chr2:62063090–62,063,115 | FAN161A |
| BRCA1 | FGFR1 | MSH2 | TP53 | MSI-4 | chr2:108479619–108,479,675 | RGPD4 |
| BRCA2 | FGFR2 | MSH6 | RET | MSI-6 | chr5:172421757–172,421,780 | ATP6V0E1 |
| BRIP1 | FGFR3 | MTOR | MSI-7 | chr6:142691947–142,691,972 | GPR126 | |
| CCND1 | FLT3 | MUTYH | MSI-8 | chr7:1787516–1,787,541 | ELFN1 | |
| CD274 | HRAS | MYC | MSI-11 | chr11:106695511–106,695,531 | GUCY1A2 | |
| CDK4 | IDH1 | NF1 | HSPH1-T17 | chr13:31722617–31,722,642 | HSPH1 | |
| CDK6 | IDH2 | NRAS | MSI-12 | chr15:45897768–45,897,790 | BLOC1S6 | |
| CDKN2A | KDR | PALB2 | MSI-13 | chr16:18882656–18,882,679 | SMG1 | |
| CDH1 | KIT | PDCD1 | MSI-14 | chr17:19314914–19,314,940 | RNF112 | |
| CTLA4 | KRAS | PDGFRA | EWSR1 | chr22:29696465–29,696,489 | EWSR1 | |