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. 2020 Jul 11;20:220. doi: 10.1186/s12876-020-01362-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Pathological examination of the lung and pancreas. a-d Transbronchial lung biopsies: The cancerous cells show pleomorphic atypical cells containing hyperchromatic nuclei in the pulmonary lesion, forming abortive glands and solid nests with fibrous stroma (a, HE, original magnification × 200). Immunohistochemical stains show cytokeratin (CK)-7-positive (b, original magnification × 200) and programmed death ligand-1 (PD-L1) cancer cells (c, original magnification × 200). Leukocyte common antigen (LCA) is also positive in stromal cells (d, original magnification × 200). e-j Pancreatic lesion: The hard tumor is located on the ventral side of the tail of the pancreas with anterior invasion to the stomach (dotted circle in e). Sarcomatoid appearance with spindle-shaped cells and pleomorphic multinucleated cells (f, HE, original magnification × 200). Osteoclast-like giant cells (OGCs) are also seen (arrows) in the tumor (g, HE, original magnification × 400). Immunohistochemistry: CK-7 (h) and PD-L1 (i) are also positive. Small amount of lymphocytic infiltration around the cancer cells was observed in LCA staining (j, original magnification × 200)