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. 2020 Jul 11;20:303. doi: 10.1186/s12935-020-01395-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — MRTF-A was crucial for miR-155 activation induced by Wnt signaling (a, c) MRTF-A and miR-155 RNA levels were concurrently upregulated in LiCl-treated SGC-7901cells. b MRTF-A protein expression was upregulated in LiCl-treated MCF-7 cells. a–c Cells were treated with 2.5 mM LiCl for 24 h. Depletion of MRTF-A abolished the LiCl-induced upregulation of miR-155 in SGC-7901 cells. d, f MRTF-A and miR-155 RNA levels were concurrently increased in Wnt3a-treated SGC-7901 cells. e MRTF-A protein expression was concurrently induced in Wnt3a-treated SGC-7901 cells. d–g Cells were treated with 10 μM Wnt3a for 24 h. Depletion of MRTF-A abolished the Wnt3a-induced upregulation of miR-155 in SGC-7901 cells (g, i) Knockout of β-catenin concurrently decreased MRTF-A and miR-155 expression in SGC-7901 cells. h MRTF-A protein expression was decreased in si-β-catenin-treated SGC-7901 cells. Data are shown as the mean ± S.E.M, based on three to six independent experiments. **, p < 0.01