Table 3.
Regression models with significant (p < 0.05) association of inflammatory markers and IGFBP-1 concentrations with maternal and neonatal outcomes
| Independent variable | Outcome | β-estimate [95% CI] (p-value) | n total |
|---|---|---|---|
| Baseline | |||
| non-pIGFBP-1 | total GWG (kg/SD) | −1.2 [− 2; −0.64] (< 0.001)* | 201 |
| MMP-8 | late GWG (kg/SD) | 0.41 [0.022; 0.77] (0.035) | 202 |
| non-pIGFBP-1 | late GWG (kg/SD) | 0.45 [−0.87; − 0.13] (0.021) | 202 |
| hsCRP | length of gestation (weeks/SD) | 0.2 [0.028; 0.36] (0.044) | 202 |
| high-pIGFBP-1 | induction of labor (OR/SD)† | 0.67 [0.48; 0.92] (0.0094) | 202 |
| non-pIGFBP-1 | birth weight (SD/SD) | −0.15 [−0.32; − 0.052] (0.027) | 198 |
| 36 gestational weeks | |||
| non-pIGFBP-1 | total GWG (kg/SD) | −1.1 [−1.8; −0.52] (0.0027)* | 188 |
| non-pIGFBP-1 | late GWG (kg/SD) | −0.55 [− 0.96; − 0.21] (0.0069) | 189 |
| non-pIGFBP-1 | cesarean section (OR/SD)‡ | 0.49 [0.24; 0.84] (0.043) | 189 |
| MMP-8 | birth weight (SD/SD) | −0.17 [− 0.34; − 0.037] (0.022) | 185 |
Both metformin and insulin treated patients were included. Induction of labor was performed in 92 and cesarean section in 26 women. Data is given as regression β-estimates or odds ratios (OR) in respect to one SD change of the predictor [95% confidence interval, CI] (p-value). The reference groups for binary outcomes were no induction of labor (†) and vaginal delivery (‡). SD = standard deviation, GWG = (maternal) gestational weight gain, pIGFBP-1 = phosphorylated insulin-like growth factor-binding protein 1, MMP-8 = matrix metalloproteinase 8, hsCRP = high sensitivity CRP. *p < 0.0045 (Bonferroni)