Table 1.

Clinical characteristics in randomized controlled studies (RCT).

	China (n = 19)	Studies Outside China (n = 44)	p-Value
Planned Enrollment	136.2 ± 114.6	1944.9 ± 6109.6	0.204
Blinded	11 (57.9%)	24 (54.5%)	0.806
Multicenter	7 (36·8%)	16 (36·4%)	0.971
Multi-Country	0 (0%)	3 (6·8%)	0.547
Sponsor (Industry)	1 (5.3%)	10 (22.7%)	0.150
	Blinded (n = 35)	Open Label (n = 28)
Planned Enrollment	1933.8 ± 6817.7	731.4 ± 1303.5	0.362
China	11 (31.4%)	8 (28.6%)	0.806
Multicenter	9 (25.7%)	14 (50.0%)	0.047
Multi-Country	1 (2.9%)	2 (7.1%)	0.560
Sponsor (Industry)	7 (20.0%)	4 (14.3%)	0.553
	Multicenter (n = 23)	Single Center (n = 40)
Planned enrollment	959.9 ± 1719.9	1652.2 ± 6358.2	0.612
China	7 (30.4%)	12 (30.0%)	0.971
Blinded	9 (39.1%)	26 (65.0%)	0.047
Multi-Country	3 (13.0%)	0 (0%)	0.045
Sponsor (Industry)	5 (21.7%)	6 (15.0%)	0.498
	Multi-Country (n = 3)	Single Country (n = 60)
Planned Enrollment	2573.3 ± 3058.5	1340.7 ±5249.2	0.690
China	0 (0%)	19 (31.7%)	0.547
Blinded	1 (33.3%)	34 (56.7%)	0.427
Multicenter	3 (100%)	20 (33.3%)	0.045
Sponsor (Industry)	3 (100%)	8 (13.3%)	0.004
	Sponsor (Industry) (n = 11)	Researcher (n = 52)
Planned Enrollment	905.8 ± 1744.6	1503.9 ± 5627.4	0.730
China	1 (9.1%)	18 (34.6%)	0.150
Blinded	7 (63.6%)	28 (53.8%)	0.741
Multicenter	5 (45.5%)	18 (34.6%)	0.511
Multi-Country	3 (27.3%)	0 (0%)	0.004

Data are mean ± SD or number (percentage) of patients.