Table 3.
Comparison of characteristics between smokers and nonsmokers with lung cancer
| Characteristics | Smokers | Nonsmokers | P |
|---|---|---|---|
| Age >60 | 797/1363 (58.5) | 154/425 (36.2) | <0.001 |
| Female | 96/1363 (7) | 203/425 (47.8) | <0.001 |
| Education (above primary level education) | 489/1120 (43.7) | 182/358 (50.8) | 0.018 |
| Morphology | |||
| ADC | 340/1363 (24.9) | 265/425 (62.3) | <0.001 |
| SCC | 476/1363 (34.9) | 42/425 (9.9) | |
| Small cell carcinoma | 261/1363 (19.1) | 32/425 (7.5) | |
| NSCLC-NOS | 266/1363 (19.5) | 55/425 (13) | |
| EGFR mutation positivity, n (%) | 23/129 (17.8) | 37/117 (31.6) | 0.012 |
| ALK rearrangement positivity, n (%) | 5/94 (5.3) | 15/84 (17.9) | 0.014 |
| ECOG 0, 1 | 555/1099 (50.5) | 191/371 (51.5) | 0.744 |
| Stage | |||
| NSCLC (before January 1, 2017) | |||
| Stage 1 or 2 | 46/788 (5.8) | 8/239 (3.4) | <0.001 |
| Stage 3 | 274/788 (34.8) | 35/239 (14.6) | |
| Stage 4 | 468/788 (59.4) | 196/239 (82.0) | |
| Ist January, 2017 onward | |||
| Stage 1 or 2 | 9/263 (3.4) | 6/122 (4.9) | <0.001 |
| Stage 3 | 97/263 (36.9) | 20/122 (16.4) | |
| Stage 4 | 157/263 (59.7) | 96/122 (78.7) | |
| Small cell carcinoma | |||
| Limited stage | 62/244 (25.4) | 6/26 (23.1) | 0.794 |
| Extensive stage | 182/244 (74.6) | 20/26 (76.9) | |
| Treatment received | 733/1334 (54.9) | 249/399 (62.4) | 0.008 |
| Median overall survival (months) | 8.0 (3.23-16.6) | 14.4 (4.9-NR) | <0.001 |
All values in n (%). NR: Not reached, ECOG: Eastern cooperative oncology group, EGFR: Epidermal growth factor receptor, ALK: Anaplastic lymphoma kinase, ADC: Adenocarcinoma, SCC: Squamous cell carcinoma, SCLC: Small-cell lung cancer, NSCLC: Non-SCLC, NOS: Not otherwise specified