Table 1.
Days in hospital | Patient 1 | Patient 2 | Patient 3 | Patient 4 | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 1 | 2 | 4 | 5 | 6 | 7 | 1 | 2 | 3 | 4 | 7 | 1 | 2 | 3 | 7 | |
Hemoglobin (g/dL) | 13.6 | 13.2 | 12.4 | 12 | 11.6 | 11.6 | 11.8 | 12.7 | 12.8 | 13 | 13.3 | 14.5 | 14.8 | 12.4 | 11.8 | 11.3 | 10.9 | 13.3 | 12.9 | 13.3 | 13.4 | 13 |
TLC (cells/µL) | 15,200 | 14,800 | 13,800 | 14,900 | 12,900 | 12,600 | 8500 | 14,000 | 11,500 | 11,700 | 12,400 | 10,700 | 8600 | 7000 | 7500 | 8900 | 10,000 | 6400 | 4300 | 6400 | 5600 | 4300 |
Neutrophils (%) | 96.6 | 94.1 | 95.5 | 94.9 | 91.4 | 91.9 | 76 | 90 | 87.4 | 80.2 | 78 | 79 | 74 | 80.6 | 82.7 | 82 | 82 | 84 | 80 | 84.9 | 81 | 66 |
Lymphocytes (%) | 2.6 | 3.7 | 3.5 | 3.1 | 4.3 | 4.3 | 13 | 4 | 6.2 | 7.1 | 7.6 | 9.7 | 12 | 14.6 | 11.7 | 14 | 10.8 | 10 | 13.7 | 10.1 | 13 | 24 |
Eosinophils (%) | 0.4 | 0.3 | 0.2 | 0 | 2.2 | 1.6 | 3.2 | 0.1 | 1.2 | 4.7 | 6.4 | 5.3 | 5 | 0.3 | 0.9 | 1.4 | 2.7 | 4 | 0.7 | 0.7 | 1.6 | 2 |
Platelet count, cells/µL (×109) | 510 | 507 | 513 | 528 | 507 | 513 | 532 | 243 | 289 | 381 | 411 | 454 | 537 | 112 | 299 | 247 | 348 | 495 | 189 | 204 | 221 | 289 |
CRP (mg/L) | 251 | 254 | 277 | 176 | 127 | 103 | 29 | 244 | 108 | 77 | 17.4 | 10.9 | 100 | 176 | 155 | 107 | 18 | 32 | 52 | 55 | 33 | |
Procalcitonin (ng/mL) | 0.02 | 0.03 | - | - | - | - | 0.01 | 0.09 | 0.07 | 0.2 | - | - | 0.04 | 0.08 | 0.08 | - | - | - | - | 0.03 | - | 0.03 |
FiO2 | 0.6 (RBM) | 0.5 | 0.3 | 0.28 | 0.24 | 0.24 | 0.21 | 0.36 | 0.36 | 0.28 | 0.24 | 0.21 | 0.21 | 0.5 | 0.4 | 0.28 | 0.21 | 0.28 | 0.24 | 0.24 | 0.21 | |
SpO2 | 89 | 94 | 94 | 94 | 95 | 98 | 98 | 93 | 94 | 96 | 94 | 94 | 93 | 85 | 94 | 94 | 94 | 95 | 94 | 94 | 97 | 98 |
PaO2:FiO2 ratio | 170 | 200 | 250 | 250 | 280 | 300 | 300 | 220 | 280 | 290 | 300 | 330 | 273 | 200 | 220 | 221 | 250 | 300 | 221 | 250 | 263 | 300 |
RR | 40 | 35 | 35 | 35 | 30 | 20 | 18 | 35 | 30 | 22 | 20 | 19 | 25 | 35 | 25 | 20 | 20 | 20 | 32 | 25 | 25 | 20 |
D-dimer | 3619 | 1799 | 1795 | 2033 | 1586 | - | 1081 | 428 | 422 | 333 | 309 | 690 | 710 | 289 | 249 | 317 | 339 | 126 | 127 | 172 | 550 | 590 |
CKMB | 35 | 65 | 47 | 71 | 44 | 50 | ||||||||||||||||
AST (U/L) | 207 | 225 | 92 | 110 | 111 | 71 | 76 | 32 | 28 | 27 | 24 | 29 | 36 | 34 | 34 | 43 | 51 | 57 | 43 | 49 | 49 | |
ALT (U/L) | 236 | 259 | 156 | 156 | 156 | 131 | 125 | 32 | 39 | 34 | 32 | 39 | 26 | 30 | 30 | 36 | 69 | 88 | 54 | 55 | 56 | |
SAP (U/L) | 97 | 102 | 86 | 100 | 123 | 122 | 115 | 114 | 107 | 96 | 86 | 83 | 82 | 89 | 105 | 125 | 147 | 130 | 43 | 39 | 40 | |
S. cr (mg/dL) | 1.1 | 1.2 | 0.7 | 0.7 | 0.7 | 0.7 | 0.8 | 0.7 | 0.8 | 0.8 | 0.8 | 0.5 | 0.5 | 0.5 | 0.4 | 0.4 | 1.2 | 0.8 | 0.9 | 0.9 | ||
Albumin (g/dL) | 3.2 | 3.1 | 2.6 | 2.6 | 2.6 | 2.7 | 2.7 | 3.2 | 3.1 | 3 | 2.9 | 3.22 | 3.4 | 3.4 | 3.3 | 3 | 3.3 | 4 | 3.8 | 3.6 | 3.4 | |
Adverse event due to Mw | Mild erythema at injection site | None | Mild erythema at injection site | None |
ALT: Alanine aminotransferase, AST: Aspartate aminotransferase, CKMB: Creatine kinase–myocardial band, RBM: rebreathing mask, RR: Respiratory rate, SAP: Serum alkaline phosphatase, S. cr: Serum creatinine, SPO2: Peripheral capillary oxygen saturation by pulse oximeter, FiO2: Fraction of oxygen in inspired air, PaO2: Partial pressure of oxygen in arterial blood, TLC: Total leukocyte count, Mw: Mycobacterium w, CRP: C-reactive protein