Classification and Corresponding ICD-10 Diagnosis Codes [2]
Sepsis, severe sepsis, septic shock
A40 Streptococcal sepsis A41 Other sepsis A48.3 Toxic shock syndrome T81.12 Postprocedural septic shock R65.2 Severe sepsis R65.20 Severe sepsis without septic shock R65.21 Severe sepsis with septic shock R65.X SIRS, unspecified
Components of sepsis
Fever R50 Fever of other and unknown origins Tachycardia R00.0 Tachycardia, unspecified R00.2 Palpitations, tachypnea R06.82 Tachypnea, unspecified R06.02 Shortness of breath, altered mental status R41.82 Altered mental status, unspecified; hypoglycemia E16.1 Other hypoglycemia E16.2 Hypoglycemia, unspecified; hyperglycemia R73.9 Hyperglycemia, unspecified; leukocytosis
D72.82 Elevated white blood cell count D72.825 Bandemia D72.828 Other elevated white blood cell count D72.829 Elevated white blood cell count, unspecified; leukopenia D72.81 Decreased white blood cell count; hypotension I95.X Hypotension R03.1 Nonspecific low blood pressure reading, hypoxemia R06.00 Dyspnea, unspecified R09.02 Hypoxemia, oliguria R34.X Oliguria N18.6 End-stage renal disease N17.X Acute kidney failure N19 Unspecified kidney failure N99.0 Postprocedural (acute) (chronic) kidney failure, coagulation abnormalities D65 Disseminated intravascular coagulation [defibrination syndrome] R79.1 Abnormal coagulation profile, thrombocytopenia D69.4 Other primary thrombocytopenia D69.5 Secondary thrombocytopenia D69.6 Thrombocytopenia, unspecified; hyperbilirubinemia E80.7 Disorder of bilirubin metabolism, unspecified; acute lung injury/acute respiratory failure; respiratory failure J96.X Respiratory failure, not elsewhere classified J95.82 Postprocedural respiratory failure J96 Respiratory failure, not elsewhere classified J98.1 Pulmonary collapse J96.0 Acute respiratory failure J96.00 Acute respiratory failure, unspecified whether with hypoxia or hypercapnia
J96.01 Acute respiratory failure with hypoxia J96.02 Acute respiratory failure with hypercapnia Z99.11 Dependence on respirator (ventilator) J96.X Respiratory failure, not elsewhere classified
Physiologic risk factors
Advanced age ≥70 y
Malignancy C00, C01, C02, C03, C04, C05, C06, C07, C08, C09, C10, C11, C12, C13, C14, C15, C16, C17, C18, C19, C20, C21, C22, C23, C24, C25, C26, C30, C31, C32, C33, C34, C37, C38, C39, C40, C41, C43, C45, C46, C47, C48, C49, C50, C51, C52, C53, C54, C55, C56, C57, C58, C60, C61, C62, C63, C64, C65, C66, C67, C68, C69, C70, C71, C72, C73, C74, C75, C76, C81, C82, C83, C84, C85, C88, C90, C91, C92, C93, C94, C95, C96, C97
Kidney dysfunction or significant renal disease N18.6 End-stage renal disease N17.X Acute kidney failure N19 Unspecified kidney failure I12.0 Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end-stage renal disease I13.11 Hypertensive heart and chronic kidney disease without heart failure with stage 5 chronic kidney disease or end-stage renal disease N99.0 Postprocedural (acute) (chronic) kidney failure I13.2 Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease or end-stage renal disease N18.6 End-stage renal disease
Hepatic dysfunction/significant liver disease or cirrhosis K91.82 Postprocedural hepatic failure K70 Alcoholic liver disease K71 Toxic liver disease K72 Hepatic failure, not elsewhere classified K74 Fibrosis and cirrhosis of liver K75 Other inflammatory liver diseases K76 Other diseases of liver K77 Liver disorders in diseases classified elsewhere B15-B19 hepatitis P78.81 congenital cirrhosis of liver
Hypoalbuminemia R77.0 Abnormality of albumin
Significant cardiovascular compromise R94.3 Abnormal results of CV function studies R55 Syncope and collapse

Derived from Mazuski et al. [2].

Abbreviations: CV, Cardiovascular; ICD-10, International Classification of Diseases, Tenth Revision; SIRS, Systemic inflammatory response syndrome.