Table 3.
Studies Identified Using Our Search Strategy That Investigate the Relationship Between OSA and IIH
| Authors, Year | Number of Patients | Type of Study | OSA Diagnostic Test | Findings |
|---|---|---|---|---|
| Doyle et al42 1991 | 1 | Case report | Medical history | Obese patient with OSA and IIH presenting with unilateral vision loss who improved following a lumboperitoneal shunt and tracheotomy |
| Purvin et al43 2000 | 1 | Case report | Medical history | Obese patient with a 2-year history of OSA presenting with unilateral vision loss, papilledema and high ICP during sleep |
| Marcus et al44 2001 | 14 IIH patients with symptoms of sleep disturbance | Retrospective | PSG | 6/14 (42.9%) of the patients had OSA |
| Lee et al45 2001 | 18 men with IIH | Retrospective | Medical history | 6/18 (33.3%) of the patients had OSA |
| Thambisetty46 et al 2006 | 16 fulminant IIH female patients | Prospective observational | Medical history | None of the patients had OSA |
| Bruce et al47 2009 | 721 IIH patients | Retrospective | Medical history | 25/655 (4%) of the female patients had OSA as opposed to 16/66 (24%) of the male patients |
| Fraser et al48 2010 | 24 IIH male patients and 48 sex-, age-, race-, and BMI category-matched controls | Prospective comparative | Berlin Questionnaire (BQ) for OSA | Following adjustments for BMI, IIH patients had a higher likelihood of having a positive Berlin questionnaire or history of OSA diagnosis |
| Thurtell et al49 2011 | 30 newly-diagnosed IIH patients | Prospective | PSG and BQ | PSG: 18/30 (60%) of the patients had OSA BQ: 20/30 (67.8%) of patients were at high risk of OSA |
| Javaheri et al50 2011 | 1 | Case report | PSG | Female patient with IIH who was diagnosed with OSA. Her IIH improved following CPAP therapy for OSA |
| Stein et al20 2011 | 2,259,061 patients, 156,336 of whom diagnosed with OSA | Retrospective | Medical history | OSA patients who did not use CPAP had an IIH diagnosis rate of 0.04% as opposed to 0.01% in the controls |
| Szewka et al51 2013 | 414 IIH patients | Retrospective | Medical history | In patients with BMI of <40, 13/256 (5.1%) had OSA as opposed to 26/158 (16.5%) in patients with BMI >40 |
| Abraham et al52 2013 | 22 IIH and 12 sex- and age-matched controls | Prospective comparative | Bedside overnight respiratory monitoring | AHI scores of IIH patients higher than the control, but both values within the normal range |
| Thurtell et al53 2013 | 24 IIH patients | Prospective observational | PSG | 8/24 (33.3%) of IIH patients had OSA. The AHI scores of the IIH patients and 1741 randomly sampled individuals had no statistical difference |
| Wardly et al54 2017 | 1 | Case report | PSG | Patient with OSA and IIH. Her IIH went away following a clockwise maxillomandibular advancement surgery to treat OSAS |
| Cappuzzo et al55 2018 | 18 IIH patients | Retrospective | Medical history | 3/18 (16.7) of IIH patients had OSA |
| Ardissino et al56 2019 | 607 IIH patients and 230,792 controls all with BMI>30 | Retrospective | Medical history | 4/607 (0.7%) of IIH patients and 2204/230,792 (1%) of the controls had OSA |
| Radojicic et al57 2019 | 219 IIH patients and 67 controls | Prospective comparative | Medical history | 5/219 (2.3%) of IIH patients and 7/67 (10.4%) of the controls had OSA |
| Onder et al58 2019a | 1 | Case report | Epworth Sleepiness Scale (ESS) | Patient with OSA and malignant IIH that was resolved following tonsillectomy to treat OSA |
| Onder et al59 2019b | 1 | Case report | ESS | 10 year-old patient with a BMI of 20, diagnosed with IIH and suspected of OSA |
Abbreviations: OSA, obstructive sleep apnea; NAION, non-arteritic anterior ischemic optic nerve; PSG, polysomnogram; CPAP, continuous positive air pressure.