Table 3.
Univariable and Multivariable Cox Proportional Hazard Models of Local Recurrence After Surgery for LSCC
| Univariable Analysis | Multivariable Analysis | |||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age ≥ 60 (yr) | 0.82 (0.59, 1.14) | 0.245 | ||
| Gender (Female) | 0.90 (0.33, 2.44) | 0.839 | ||
| BMI (kg/m2) | 1.02 (0.96, 1.07) | 0.590 | ||
| Smoking | 1.12 (0.76, 1.65) | 0.579 | ||
| Alcohol intake | 0.55 (0.36, 0.83) | 0.005* | 0.058 | |
| ASA | 1.00 (0.72, 1.39) | 0.985 | ||
| Cancer history | 0.58 (0.18, 1.82) | 0.348 | ||
| Opioids (morphine, mg) | 0.99 (0.99, 1.01) | 0.848 | ||
| Types of surgery | 2.86 (1.86, 4.42) | <0.001* | 3.13 (2.03, 4.84) | <0.001** |
| Neck dissection | 0.92 (0.66, 1.27) | 0.590 | ||
| Intubation | 1.08 (0.78, 1.51) | 0.630 | 0.595 | |
| Anesthesia time | 0.94 (0.83, 1.07) | 0.361 | ||
| Primary site of cancer | 0.001* | 0.003** | ||
| Supraglottic | Reference | Reference | ||
| Glottic | 3.59 (1.89, 6.84) | <0.001* | 2.69 (1.39, 5.21) | 0.003** |
| Subglottic | 3.41 (0.94. 12.40) | 0.063 | 2.02 (0.55, 7.39) | 0.290 |
| Tumor differentiation | 0.140 | 0.697 | ||
| T classification | 1.15 (0.96, 1.37) | 0.129 | 0.608 | |
| N classification | 0.004* | 0.004** | ||
| 0 | Reference | Reference | ||
| 1 | 0.56 (0.30, 1.03) | 0.063 | 0.61 (0.33, 1.15) | 0.127 |
| 2 | 0.24 (0.09, 0.64) | 0.005* | 0.27 (0.10, 0.75) | 0.012** |
| Clinical stage | 1.06 (0.89, 1.27) | 0.498 | ||
| Preoperative radiotherapy | 0.98 (0.43, 2.21) | 0.951 | ||
| Preoperative chemotherapy | 0.51 (0.13, 2.06) | 0.343 | ||
| Postoperative radiotherapy | 0.93 (0.61, 1.43) | 0.750 | ||
| Postoperative chemotherapy | 1.21 (0.62, 2.39) | 0.574 | ||
Notes: *P<0.1, **P<0.05 is statistically significant.
Abbreviations: LSCC, laryngeal squamous cell carcinoma; HR, hazard ratio; BMI, body mass index; ASA, American society of Anesthesiology; T classification, tumor classification of tumor, node and metastasis classification of cancer; N classification, node classification of tumor, node and metastasis classification of cancer.