Table 4.
Univariable and Multivariable Cox Proportional Hazard Models of Lymphatic Metastasis After Surgery for LSCC
| Univariable Analysis | Multivariable Analysis | |||
|---|---|---|---|---|
| HR(95% CI) | P value | HR(95% CI) | P value | |
| Age ≥ 60 (yr) | 0.89 (0.45, 1.74) | 0.727 | ||
| Gender (Female) | 0.88 (0.12, 6.42) | 0.898 | ||
| BMI (kg/m2) | 0.85 (0.75, 0.96) | 0.007* | ||
| BMI classification (kg/m2) | 0.774 | 0.620 | ||
| 18.5 ≤ BMI < 25 | Reference | |||
| BMI < 18.5 | 0.80 (0.28, 2.30) | 0.682 | ||
| BMI ≥ 25 | 0.71 (0.25, 2.03) | 0.525 | ||
| Smoking | 1.02 (0.46, 2.28) | 0.953 | ||
| Alcohol intake | 1.29 (0.63, 2.65) | 0.490 | ||
| ASA | 0.92 (0.47, 1.81) | 0.806 | ||
| Cancer history | 1.77 (0.42, 7.37) | 0.435 | ||
| Opioids (morphine, mg) | 0.99 (0.97, 1.00) | 0.103 | 0.061 | |
| Types of surgery | 1.25 (0.59, 2.62) | 0.553 | ||
| Neck dissection | 1.12 (0.56, 2.22) | 0.751 | ||
| Intubation | 0.93 (0.47, 1.84) | 0.838 | ||
| Anesthesia time | 0.93 (0.72, 1.23) | 0.629 | ||
| Primary site of cancer | 0.56 (0.23, 1.13) | 0.104 | 0.237 | |
| Tumor differentiation | 1.48 (0.86, 2.56) | 0.157 | ||
| T classification | 1.20 (0.82, 1.76) | 0.339 | 0.647 | |
| N classification | 1.27 (0.81, 2.00) | 0.302 | 0.933 | |
| Clinical stage | 1.16 (0.80, 1.68) | 0.428 | 0.270 | |
| Preoperative radiotherapy | 2.02 (0.62, 6.62) | 0.244 | ||
| Preoperative chemotherapy | 1.03 (0.14, 7.54) | 0.976 | ||
| Postoperative radiotherapy | 0.78 (0.30, 2.02) | 0.611 | ||
| Postoperative chemotherapy | 5.18 (2.25, 11.91) | <0.001* | 5.18 (2.57, 11.91) | <0.001** |
Notes: *P<0.1, **P<0.05 is statistically significant.
Abbreviations: LSCC, laryngeal squamous cell carcinoma; HR, hazard ratio; BMI, body mass index; ASA, American society of Anesthesiology; T classification, tumor classification of tumor, node and metastasis classification of cancer; N classification, node classification of tumor, node and metastasis classification of cancer.