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. 2020 Jul 7;14:2645–2655. doi: 10.2147/DDDT.S255823

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© 2020 Li et al.

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MiR-766-3p targets AIFM1 to regulate autophagy and cell apoptosis in chondrocytes. (A) Luciferase activity of a dual-luciferase reporter vector containing wild-type 3ʹUTR-AIFM1 or a mutant 3ʹUTR-AIFM1. (B and C) AIFM1 expression at mRNA and protein was determined by qRT-PCR (B) and Western blot (C) in IL-1β alone treated, IL-1β + baicalin treated, NC in, miR-766-3p in transfected human OA chondrocytes. (D) After miR-766-3p or AIFM1 transfection, chondrocytes were treated with IL-1β for 24 h. The apoptosis rate was measured by flow cytometry analysis. **p < 0.01, ^&& p<0.01,^## p<0.01.