Table 1.
Demographic data and plasma concentrations of 16 steroids in subjects of the control group (reference population and subjects in whom hypercortisolism was excluded) compared to subjects with adrenal Cushing syndrome (ACS; mainly cortisol-producing adrenocortical adenomas) and subjects with PBMAH with and without damaging germline variants in ARMC5.
| Control Group | ACS Group | PBMAH Group | |||
|---|---|---|---|---|---|
| Reference | Excluded | ARMC5 -ve | ARMC5 +ve | ||
| Demographic data | |||||
| Sex (M/F) | · | 40/69 | 3/16 | 7/17 | 7/5 |
| Age (years) | 50 | 51 | 45 | 59 | 52 |
| (31–81) | (31–80) | (17–72) | (31–74) | (39–68) | |
| Plasma steroids (ng/mL) | |||||
| Cortisol | 84 | 97 | 163 * | 100 | 102 |
| (66–106) | (71–134) | (85–185) | (75–132) | (80–128) | |
| 11-Deoxycortisol | 0.13 | 0.14 | 0.44 *† | 0.44 *† | 0.48 *† |
| (0.09–0.19) | (0.09–0.24) | (0.33–0.92) | (0.25–0.78) | (0.30–1.14) | |
| Cortisone | 16.7 | 17.7 | 18.6 | 13.4 | 13.4 |
| (14.4–19.6) | (13.7–22.0) | (14.9–23.5) | (11.7–18.4) | (10.7–19.0) | |
| Corticosterone | 1.50 | 1.41 | 2.20 | 2.55 | 4.71 *† |
| (1.04–2.60) | (0.85–2.54) | (1.23–3.86) | (1.24–4.81) | (1.62–7.52) | |
| 11-Deoxycorticosterone | 0.02 | 0.03 | 0.09 *† | 0.06 *† | 0.12 *† |
| (0.01–0.05) | (0.02–0.05) | (0.06–0.20) | (0.03–0.17) | (0.09–0.30) | |
| 18-Hydroxycortisol | 0.57 | 0.79 * | 0.76 | 1.11 *† | 1.47 *† |
| (0.37–0.80) | (0.51–1.27) | (0.45–2.03) | (0.88–1.89) | (0.90–2.95) | |
| 21-Deoxycortisol | 0.010 | 0.009 | 0.011 | 0.019 | 0.025 |
| (0.003–0.022) | (0.011–0.023) | (0.004–0.060) | (0.004–0.045) | (0.002–0.052) | |
| Aldosterone | 0.04 | 0.05 | 0.06 | 0.07 * | 0.05 |
| (0.02–0.07) | (0.03–0.10) | (0.03–0.179) | (0.04–0.12) | (0.03–0.12) | |
| 18-Oxocortisol | 0.007 | 0.012 * | 0.017 * | 0.010† | 0.010 |
| (0.001–0.049) | (0.003–0.330) | (0.002–0.500) | (0.010–0.042) | (0.008–0.163) | |
| Pregnenolone | 1.29 | 1.16 | 1.78 | 0.67 * | 0.96 |
| (0.84–1.80) | (0.56–1.75) | (0.16–4.09) | (0.46–0.98) | (0.62–1.25) | |
| 17-Hydroxyprogesterone | 0.32 | 0.44 | 0.36 | 0.24 | 0.33 |
| (0.17–0.82) | (0.24–0.78) | (0.17–1.54) | (0.15–0.62) | (0.24–0.50) | |
| Progesterone | 0.09 | 0.09 | 0.09 | 0.02 *† | 0.03 *† |
| (0.07–0.17) | (0.07–0.13) | (0.02–0.21) | (0.00–0.07) | (0.01–0.06) | |
| DHEA | 2.33 | 2.05 | 0.59 *† | 0.22 † | 0.07 *† |
| (1.48–3.36) | (1.18–3.96) | (0.38–0.95) | (0.02–1.24) | (0.02–1.30) | |
| DHEA-S | 1340 | 1010 | 204 *† | 371 *† | 267 *† |
| (794–1830) | (621–1895) | (103–419) | (193–939) | (96–664) | |
| Androstenedione | 0.82 | 0.83 | 0.49 | 0.50 *† | 0.50* |
| (0.61–1.13) | (0.55–1.26) | (0.33–1.21) | (0.28–0.91) | (0.27–0.81) | |
| Testosterone | 0.31 | 0.36 | 0.16 * | 0.18 * | 1.25 |
| (0.19–3.55) | (0.17–2.98) | (0.10–0.49) | (0.08–0.52) | (0.17–3.33) | |
Ages are shown as medians and ranges and all plasma concentrations as medians and interquartiles.
*
P<0·05, different from reference;
†
P<0·05, different from excluded.