Table 1.
Clinical Review of 6 Reports of L-FLAC with Genetic Analysis
| Author | Age/Sex | β-Catenin Expression | Size | Genetic Mutation |
|---|---|---|---|---|
| Nakatani et al, 20024 | N/A N/A |
Nuclear/cytoplasmic expression nuclear/cytoplasmic expression |
N/A N/A |
CTNNB1 (the exon 3, c.101G>T, p.G34V) CTNNB1 (the exon 3, c.110C>G, p.S37C) |
| Sekine et al, 200315 | 32/F | Nuclear/cytoplasmic expression | 3.2cm | CTNNB1 (the exon 3, c.94G>T, p.A32T) |
| 22/F | Nuclear/cytoplasmic expression | 2.8cm | CTNNB1 (the exon 3, c.98C>G, p.S33C) | |
| 23/M | Nuclear/cytoplasmic expression | 3.0cm | CTNNB1 (the exon 3, c.110C>G, p.S37C) | |
| Wu et al, 2014;12 de Kock et al, 201613 | 16/F | Mostly membranous, with multifocal nuclear/cytoplasmic expression | 6.7cm |
CTNNB1 (the exon 3, c.98C>G, p.S33C) DICER1 (the exon 21, c.3540C>A, p.Tyr1180; the exon 24, c.5127T>A, p.A1709G) |
| Fu et al, 201816 | 31/M | Nuclear/cytoplasmic expression | 3.0cm |
CTNNB1 (the exon 3, c.110C > A, p.S37Y) BRCA2 (the exon 10, c.1871C>T, p.C624V) TSC2 (the exon 12, c.1222T>G, p.F408V) |
| 21/M | Nuclear/cytoplasmic expression | 5.8cm |
CTNNB1 (the exon 3, c.110C > G, p.S37C) DDR2 (p.E499) |
|
| Present case | 39/F | Diffusive membranous, with sporadic nuclear/cytoplasmic expression | 2.5cm |
CTNNB1 (the exon 3, c.98C>G, p.S33C) DICER1 (the exon 23, c.4407_4410delTTCT, p.S1470Lfs*19; the exon 24, c.5125G>A, p.D1709N) |