Table 1.
Target Genes of miRNA-154 Responsible for Its Tumor Suppressive Action in Different Cancers
| Gene | Location | Malignancy | Cell Lines | No. of Tissue Samples (Pair) | Outcomes | References | |
|---|---|---|---|---|---|---|---|
| Normal | Cancerous | ||||||
| MTDH | 8q22.1 | Gastric cancer | GES-1 | SGC-7901, AGS, MKN-1, and BGC-823 |
36 | Inhibited the proliferation, migration and invasion |
[22] |
| DIXDC1 | 11q23.1 | Gastric cancer | GES-1 | MGC-803, MKN-87, MKN-45, and AGS |
16 | Inhibited the growth and invasion | [23] |
| TRAF6 | 11p12 | Colorectal cancer | N/A | N/A | N/A | Inhibited the proliferation, migration and invasion | [25] |
| CCND1 | 11q13.3 | Colorectal cancer | N/A | N/A | N/A | Inhibited the proliferation, migration and invasion | [25] |
| TLR2 | 4q31.3 | Colorectal cancer | HEK293 | SW480, SW620, HT29 | 41 | Inhibited the proliferation, colony formation, migration and invasion | [26] |
| CCND2 | 12p13.32 | Colorectal cancer | FHC | HCT-116, HCT-8, SW-480, SW-620, DLD-1 and HT-29 |
80 | Inhibited the proliferation and growth |
[28] |
| Prostate cancer | N/A | DU145, PC-3 | 27 | Inhibited the proliferation, colony formation, and growth | [47] | ||
| Hepatocellular carcinoma | N/A | HepG2, Hep3B | N/A | Inhibited the growth, colony formation and induced cell cycle arrest at G1/S phase | [64] | ||
| GALNT7 | 4q34.1 | laryngeal squamous cell carcinoma | 16HBE | LSCC Hep-2, TU212 | 104 | Inhibited the proliferation, colony formation, migration, and induced cell cycle arrest at G0/G1 phase | [30] |
| ZEB2 | 2q22.3 | Non-small cell lung cancer | N/A | A549 | N/A | Inhibited the migration, invasion, and suppressed EMT | [34] |
| Hepatocellular carcinoma | HL-7702 | Huh-7, SMMC7721, HepG2 HCCLM3 |
50 | Inhibited the proliferation, migration, invasion and induced apoptosis, G1cell cycle arrest at G1 phase | [65] | ||
| Non-small cell lung cancer | NBE | A549, H322, H1299, GLC-82, SPC-A1 | 42 | Inhibited the proliferation, migration invasion, and induced apoptosis | [36] | ||
| RUNX2 | 6p21.1 | Non-small cell lung cancer | NBE | A549, H322, H1299, GLC-82, SPC-A1 | 42 | ||
| RUNX2 | 6p21.1 | Bladder cancer | N/A | T24 | 86 | Inhibited the proliferation, migration, invasion, and improved prognosis | [40] |
| RSF1 | 11q14.1 | ||||||
| ATG7 | 3p25.3 | Bladder cancer | SV-HUC-1 | J82, T24, UM-UC-3 |
84 | Inhibited the proliferation, migration, invasion, and decreased advanced T stage, lymphatic invasion, distant metastasis |
[39] |
| HMGA2 | 12q14.3 | Prostate cancer | N/A | DU145, PC-3 | 4 | Inhibited the migration, invasion and suppressed EMT | [46] |
| E2F5 | 8q21.2 | Prostate cancer | N/A | DU145, PC-3 | 32 | Inhibited the migration, invasion, growth, and induced cell cycle arrest at G1 phase |
[48] |
| Osteosarcoma | N/A | MG63, HOS | 30 | Inhibited the migration, proliferation, invasion and induced cell cycle arrest at G0/G1 phase | [73] | ||
| Breast cancer | MCF-10A | MCF-7, MDA-MB-231, BT-549 MDA-MB-453 |
36 | Inhibited the proliferation, migration, invasion, and increased cell arrest at the G0/G1 phase | [59] | ||
| PIWIL1 | 12q24.33 | Glioblastoma | N/A | U251, U87, A172, LN229, SNB19, LN308 | 34a | Inhibited the proliferation, metastasis and induced apoptosis | [51] |
| Glioma | NHA | A172, SNB19, U172, U251, U87MG |
40 | Inhibited the proliferation, migration and invasion | [52] | ||
| ADAM9 | 8p11.22 | Breast cancer | MCF-10A | MCF-7, SKBR3, MDA-MB-231 | 45 | Inhibited the proliferation, migration and invasion | [60] |
| NAMPT | 7q22.3 | Breast cancer | MCF-10A, HEK-293 |
MCF-7, MDA-MB-231 | N/A | Inhibited nicotinamide adenine dinucleotide (NAD) salvage pathway, increased apoptosis, and sensitivity to doxorubicin | [61] |
| BASE (BPIFA4P) |
20q11.21 | Breast cancer | N/A | N/A | 68a | N/A | [58] |
| PCNA | 20p12.3 | Breast cancer | MCF10A | MCF7, T47D, BT474, BT549, MDA-MB-468, MDAMB231 | 30 | Inhibited the proliferation and induced cell cycle arrest at G1 phase | [62] |
| Hepatocellular carcinoma | Primary Human Hepatocytes (PHH) | HepG2, HepG2.2.15, HepAD38, HepG2-NTCP |
43a | Decreased HBV replication and growth | [66] | ||
| RHOA | 3p21.31 | Thyroid cancer | Nthy-ori3-1 | K-1, TPC-1, B-CPAP | 63 | Inhibited the proliferation, growth and induced apoptosis | [70] |
| WNT5A | 3p14.3 | Osteosarcoma | NHOst | HOS, Saos-2, U2OS, MG-63 | 44 | Inhibited the proliferation, colony formation, migration, invasion and induced cell cycle arrest at G1 phase |
[74] |
| AURKA | 20q13.2 | Melanoma | HEMa-LP | SK-MEL-2, A375, 1205Lu, UACC903, CHL-1 |
104a | Inhibited the proliferation, Invasion, migration and induced apoptosis |
[76] |
| NSD2 | 4p16.3 | Skin squamous cell carcinoma | NHEK | CRL-1555, CRL-1623 | N/A | Inhibited the growth, and induced apoptosis, G0/G1cell cycle arrest | [77] |
| CCNE1 | 19q12 | Osteosarcoma | N/A | MG63, HOS | 30 | Induced cell cycle arrest at G0/G1 phase | [73] |
| CDK2 | 12q13.2 | Osteosarcoma | N/A | MG63, HOS | 30 | Induced cell cycle arrest at G0/G1 phase | [73] |
Notes: aTissue specimens are not in pairs. The genes' names were abbreviated according to GenBank.
Abbreviation: N/A, not applicable.